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Rate ePoster

Musculoskeletal and Sports Medicine

Intra-articular Therapeutic Efficacy of Intra-articular Leukocyte-Poor Platelet-rich Plasma Injections Versus Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Meta-analysis

Saturday, October 25, 2025
8:00 AM - 9:15 AM MT
Location: Kiosk 8

    Poster Presenter(s)

  • Yu-Hsiang Peng, MD

    Medical Student
    Mackay Medical College
    Taipei, Taiwan (Republic of China)

    • Co-Author(s)

  • Yuning Peng, MD

    Resident
    Chang Gung Memorial Hospital, McGill University Faculty of Medicine
    New Taipei City, Taiwan (Republic of China)

Disclosure(s):
Yu-Hsiang Peng, MD: No financial relationships to disclose
Background and/or Objectives: To evaluate the clinical effects of intra-articular leukocyte-poor platelet-rich plasma (LP-PRP) injection compared with intra-articular hyaluronic acid (HA) injection in knee osteoarthritis adult patients.

Design: Systematic Review and Meta-analysis

Setting : Medical centers at Turkey, Iran, France, South Korea, USA, China, Spain and Italy.

Participants : Adult humans (over 18 years of age) with knee osteoarthritis. A total of 983 patients were included in our meta-analysis, with 12 RCTs included. 502 patients underwent LP-PRP injection, and 481 patients underwent HA injection.

Interventions: An experimental group that received intra-articular LP-PRP injection and a control group that received intra-articular HA injection.

Main Outcome Measures: Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores (WOMAC total, pain, stiffness, and physical function scores); Visual Analog Scale (VAS) scores, EQ-VAS scores, International Knee Documentation Committee (IKDC) scores, and adverse events were used as outcome measurements to evaluating the efficacy of LP-PRP and HA treatment.

Results: After screening 377 potential articles, 12 RCTs were enrolled in this systemic review and meta-analysis. The WOMAC total scores and WOMAC physical function scores of the LP-PRP group were better than those of the HA group at 6 and 12 months. VAS scores of the LP-PRP group were better than those of the HA group at 3, 6, and 12 months. The LP-PRP group have a better outcome of IKDC scores than the HA group at 6 months. There was no significant difference in adverse events between the LP-PRP and HA groups.

Conclusions: Intra-articular injections of LP-PRP showed better overall outcomes, such as WOMAC total scores, WOMAC physical function scores, and IKDC scores, compared to HA for knee osteoarthritis adult patients at short-term and long-term follow-up periods. Also, LP-PRP showed better short-term and long-term pain relief compared to HA. Intra-articular LP-PRP improves pain relief and overall outcomes in knee osteoarthritis patients.