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General Rehabilitation

Session: Comparison in physical function of bone marrow transplant patients before and after bone marrow transplant.

Comparison in Physical Function of Bone Marrow Transplant Patients Before and After Bone Marrow Transplant

Saturday, October 25, 2025
12:00 PM - 1:30 PM MT
Location: Kiosk 9
Disclosure(s):
Adrian Cristian, MD: No relevant disclosure to display
Sandra Sepulveda, NP: No financial relationships to disclose
Background and/or Objectives: Bone marrow transplant (BMT) is an important treatment modality for several hematological malignancies and can have an adverse impact on physical function. In this study we compared physical function measures pre-and post-BMT.

Design: retrospective chart review

Setting : Cancer Institute

Participants : 96 BMT patients evaluated before/after undergoing BMT. The mean age (SD) of the population was 55.8 (13.23) and 62.50% were males. The majority of patients were Hispanic 46 (47.9%), followed by White 39 (40.6 %), African American 6 (6.3 %), and other 5 (5.2%). 43 (44.8%) had multiple myeloma, 14 (14.6%) had non-Hodgkin’s lymphoma, 12 (12.5%) had acute myeloid leukemia and 17 (28.1%) had other hematologic malignancies. 67 (69.8%) received autologous transplant and 29 ( 30.2%) received allogenic transplant.

Interventions: None

Main Outcome Measures: Physical function measures collected prior/after BMT included Patient-Reported Outcomes Measurement Information System - Physical Function (PROMIS-PF total raw score), PROMIS - Fatigue (PROMIS-F total raw score), Sit-to-Stand (STS-30 seconds) test, time up and go (TUG) test, and grip strength

Results: PROMIS-PF pre-BMT mean score was 40.6 (8.31) and post BMT mean score was 36.9 (8.34) (P < 0.001). PROMIS-F pre-BMT mean score was 15.8 (5.32) and post BMT mean score was 17.3 (5.35) (P=0.008). STS-30: pre-BMT mean score was 14.1 (6.77) and post BMT mean score was 14.3 (7.96) (P=0.459). TUG: pre-BMT mean score was 8.9 ( 3.44) and post BMT mean score was 9.7 (5.39) (P=0.171). Grip strength: pre-BMT mean score was 33.3 (13.50) and post BMT mean score was 30.8 (13.11) (P=0.002).

Conclusions: Self-reported physical function worsened pre vs post BMT. The STS-30 seconds, TUG test and grip strength demonstrated comparable values pre/post BMT indicative that objectively tested physical function was maintained during the transplant process. This study also establishes data on physical function for this population before and after BMT.