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General Rehabilitation

An Atypical Presentation of Guillain-Barre Syndrome With Descending Paralysis: A Case Report

Thursday, October 23, 2025
12:45 PM - 2:15 PM MT
Location: Kiosk 2

    Poster Presenter(s)

  • Jesse Blount, DO

    Medical student
    Nova Southeastern University Dr Kiran C Patel College of Osteopathic Medicine
    Fern Park, Florida

    • Primary Author(s)

  • Sergio Mosquera Limas, DO

    PGY-1 Physical Medicine & Rehabilitation Resident
    Yale Physical Medicine & Rehabilitation Residency
    New Haven, Connecticut

    • Co-Author(s)

  • Rebecca A. Riekki, Other (she/her/hers)

    Medical Student
    Nova Southeastern University Dr Kiran C Patel College of Osteopathic Medicine
    Margate, Florida

  • Suhana Singh, Other

    Medical Student
    Nova Southeastern University Dr Kiran C Patel College of Osteopathic Medicine
    Fort Lauderdale, North Carolina

Disclosure(s):
Jesse Blount, DO: No financial relationships to disclose
Sergio Mosquera Limas, DO: No financial relationships to disclose
Suhana Singh, Other: No financial relationships to disclose
Case Diagnosis: A 31 year old man with Guillain-Barre Syndrome

Case Description or Program Description: The patient had an atypical presentation of Guillain-Barre syndrome (GBS) with descending muscle weakness and paralysis that started at the upper extremities and progressed to the lower extremities in contrast to a typical ascending presentation that usually starts at the lower extremities. Hyporeflexia of deep tendon reflexes of the affected extremities was also present. About 2 weeks prior he had a preceding infection of cytomegalovirus with no other significant past medical history. He was admitted to the ICU for 4 days due to his rapidly deteriorating state with chest pain and shortness of breath. MRI with and without contrast of the brain and spine revealed no remarkable findings. Due to suspicion of GBS, patient was started on a course of IVIG to be completed over 5 days and plasmapheresis was to be completed over 14 days. Once hemodynamically stable patient was transferred to an acute inpatient rehab facility for further treatment. After 30 days of acute inpatient rehab he was later discharged with improvement of symptoms.

Setting: Acute care hospital

Assessment/Results: After treatment, patient demonstrated significant improvement in walking, muscle movement of the extremities, functioning in activities of daily living, and restoration of deep tendon reflexes.

Discussion (relevance): To our knowledge, this is one of very few reported cases of descending muscle weakness and paralysis of GBS.

Conclusions: Given that GBS is a rapidly deteriorating condition that can be fatal due to respiratory failure, it is vital that a diagnosis be made quickly. Diagnosis is mostly made based on clinical presentation since diagnostic biomarkers are not available for most variants of this disorder. Atypical presentations can delay diagnosis and treatment. In order to prevent this delay, it is important to be aware of atypical presentations.