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Rate ePoster

Musculoskeletal and Sports Medicine

Elevated Baseline Depressive Symptomology Effects Patient Reported Outcomes Following Platelet Rich Plasma for Knee Osteoarthritis

Saturday, October 25, 2025
8:00 AM - 9:15 AM MT
Location: Original Research Theater

    Poster Presenter(s)

  • Darby Oakes, DO, MPH

    Resident Physician
    Emory University School of Medicine PM&R Program
    Atlanta, Georgia

    • Co-Author(s)

  • NH

    Nicholas Hooper, MD

    Resident Physican
    Emory University School of Medicine PM&R Program
    Atlanta, Georgia

  • Ken Mautner, MD

    Professor
    Emory Sports Medicine
    Atlanta, Georgia

  • Prathap Jayaram, MD

    Associate Professor, Director of Regenerative and Translational Research
    Emory University School of Medicine
    Atlanta, Georgia

  • KE

    Kirk A. Easley, Other

    Research Professor
    Emory University
    Atlanta, Georgia

Disclosure(s):
Darby Oakes, DO, MPH: No financial relationships to disclose
Nicholas Hooper, MD: No financial relationships to disclose
Prathap Jayaram, MD: No financial relationships to disclose
Background and/or Objectives: Orthobiologics, especially PRP, has gathered widespread attention as a possible treatment for knee OA. Some studies have found that mental health conditions, such as depression and anxiety, can affect patients' perception of well-being. This study's objective was to evaluate if patients' baseline depressive symptomology effects patient reported outcomes following PRP.

Design: Prospective Cohort

Setting : Remote

Participants : All participants (>18 years old) seeking PRP therapy for Knee OA at a large academic institution Musculoskeletal Clinic.

Interventions: Platelet Rich Plasma Injection

Main Outcome Measures: Knee Injury and Osteoarthritic Outcome Score of Joint Replacement (KOOS Jr) and Patient Health Questionnaire-4 (PHQ-4) were obtained on day of injection. KOOS JR was then obtained at 1, 3, 6, 9 and 12 months via electronic survey.

Results: A total of 206 patients underwent PRP for Knee OA. The average age of included participants was 60.8 with a mean BMI of 28.6. The time-averaged mean KOOS- Jr score was 68.8 [95% CI: 66.1 - 71.5] for 100 patients with PHQ-4 = 0 and 60.6 [95% CI: 58.2 - 63.0) for the 106 patients with PHQ-4 Score > 0 [Mean difference: 8.2 [95% CI: 4.6 – 11.8], P < 0.001]

Conclusions: On average, patients with baseline depression symptomology had significantly worse KOOS, JR outcome scores than patients without any baseline mental health symptomatology. Given this, providers should consider screening patients in an attempt refer patients to appropriate providers to treat concomitant psychopathology in order to improve PRP outcomes.